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CAS RN: 193551-21-2 | Product Number: B5898
SB 239063
Purity: >98.0%(HPLC)
Synonyms:
- trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
Documents:
Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH | Shipping Information |
---|---|---|---|---|---|
5MG |
¥20,900
|
1 | 10 | Contact Us | |
25MG |
¥68,200
|
6 | 32 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Product Number | B5898 |
Purity / Analysis Method | >98.0%(HPLC) |
Molecular Formula / Molecular Weight | C__2__0H__2__1FN__4O__2 = 368.41 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (<0°C) |
Condition to Avoid | Heat Sensitive |
CAS RN | 193551-21-2 |
Reaxys Registry Number | 9010076 |
PubChem Substance ID | 468590774 |
MDL Number | MFCD03792786 |
Specifications
Appearance | White to Light yellow powder to crystal |
Purity(HPLC) | min. 98.0 area% |
NMR | confirm to structure |
Properties (reference)
Melting Point | 207 °C |
GHS
Related Laws:
RTECS# | GV9458000 |
Transport Information:
Application
SB 239063: A Selective p38 Mitogen-Activated Protein Kinase (MAPK) Inhibitor
SSB 239063 is a selective p38 mitogen-activated protein kinase (MAPK) inhibitor. It displays greater than 220-fold selectivity for p38 MAPK over other kinases.1) The p38 MAPK has been linked to inflammatory cytokine production and cell death in cellular stress. SB 239063 has been shown to reduce inflammatory cytokine production.1-4)
References
- 1) SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
- 2) SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
- 3) Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia (a review)
- 4) SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia
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