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CAS RN: 1895-39-2 | Product Number: C0991
Sodium Chlorodifluoroacetate
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Purity: >99.0%(T)
Synonyms:
- Chlorodifluoroacetic Acid Sodium Salt
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
¥6,200
|
7 | 3 | 38 | |
| 100G |
¥18,300
|
16 | 5 | Contact Us | |
| 500G |
¥60,900
|
1 | It can be shipped from Saitama warehouse on the same day* | It can be shipped in about 2 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C0991 |
Purity / Analysis Method 
|
>99.0%(T) |
| Molecular Formula / Molecular Weight | C__2ClF__2NaO__2 = 152.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 1895-39-2 |
| Reaxys Registry Number | 4162363 |
| PubChem Substance ID | 87566036 |
| MDL Number | MFCD00064771 |
Specifications
| Appearance | White powder to crystal |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Soluble |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
Application
Difluorocarbene Precursor (Difluorocyclopropanation Reaction)
Typical Procedure:
A solution of (E)-1 (3.6 g, 16.4 mmol) in dry diglyme (5 mL) is heated to 190 ℃. A solution of sodium chlorodifluoroacetate (27.3 g, 179 mmol) in dry diglyme (47 mL) is added at this temperature over a period of 60 minutes. After keeping the reaction at 190 ℃ for an additional 15 minutes, it is cooled to room temperature, poured into ice water and the aqueous solution is extracted with hexane (4 × 100 mL). The combined organic layers are washed with brine, dried (MgSO4), the solvents evaporated under reduced pressure and the remaining brown oil is subjected to column chromatography (SiO2, AcOEt : hexane = 1 : 8) to afford (±)-2 (2.97 g, Y. 67%) as a colorless oil.
A solution of (E)-1 (3.6 g, 16.4 mmol) in dry diglyme (5 mL) is heated to 190 ℃. A solution of sodium chlorodifluoroacetate (27.3 g, 179 mmol) in dry diglyme (47 mL) is added at this temperature over a period of 60 minutes. After keeping the reaction at 190 ℃ for an additional 15 minutes, it is cooled to room temperature, poured into ice water and the aqueous solution is extracted with hexane (4 × 100 mL). The combined organic layers are washed with brine, dried (MgSO4), the solvents evaporated under reduced pressure and the remaining brown oil is subjected to column chromatography (SiO2, AcOEt : hexane = 1 : 8) to afford (±)-2 (2.97 g, Y. 67%) as a colorless oil.
References
- Synthesis of trans-configurated spacered nucleoside analogues comprising a difluorocyclopropane moiety
- R. Csuk, L. Eversmann, Z. Naturforsch. 2003, 58b, 997.
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