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CAS RN: 6055-19-2 | Product Number: C2236

Cyclophosphamide Monohydrate


Purity: >98.0%(N)
Synonyms:
  • 2-[Bis(2-chloroethyl)amino]tetrahydro-1,3,2-oxazaphosphorin-2-oxide Monohydrate
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Product Number C2236
Purity / Analysis Method >98.0%(N)
Molecular Formula / Molecular Weight C__7H__1__5Cl__2N__2O__2P·H__2O = 279.10  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
CAS RN 6055-19-2
Related CAS RN 50-18-0
Reaxys Registry Number 8167897
PubChem Substance ID 125307342
Merck Index (14) 2747
MDL Number

MFCD00149395

Specifications
Appearance White to Almost white powder to crystal
Purity(with Total Nitrogen) min. 98.0 %(calcd.on anh.substance)
Melting point 49.0 to 53.0 °C
Water max. 8.0 %
Properties (reference)
Melting Point 51 °C
Solubility in water Slightly soluble
Solubility (very soluble in) Ethanol,Chloroform
Solubility (soluble in) Ether
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H362 : May cause harm to breast-fed children.
H340 : May cause genetic defects.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dusts or mists.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# RP6157750
Transport Information:
UN Number UN3464
Class 6.1
Packing Group III
Application
Reagent for cystitis model

References


Application
Reagent for hematopoietic disorder model

References


Application
Reagent for overactive bladder model

References


Application
Reagent for nausea or vomiting model

References


Application
Reviews on the Pharmacology of Cyclophosphamide

References

  • An overview of cyclophosphamide and ifosfamide pharmacology
    • R. A. Fleming, Pharmacotherapy 1997, 17, 146S.
  • Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
  • The chemistry of the metabolites of cyclophosphamide
    • S. M. Ludeman, Curr. Pharm. Des. 1999, 5, 627.
  • Mechanisms of resistance to the toxicity of cyclophosphamide
    • M. P. Gamcsik, M. E. Dolan, B. S. Andersson, D. Murray, Curr. Pharm. Des. 1999, 5, 587.


Application
Preparation

Reference


Application
Optical resolution study

Reference


PubMed Literature


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