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CAS RN: 470-37-1 | Product Number: C3460
Cinobufagine
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Purity: >98.0%(HPLC)
Synonyms:
- 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-Acetate
- Cinobufagin
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
More Stock Info
|
|---|---|---|---|---|---|
| 25MG |
¥27,500
|
1 | |||
| 100MG |
¥79,200
|
5 | 3 | 10 |
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* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* For the case that without specific estimated shipping data, e.g.: If displayed as "will be shipped after 8 working days", the products will be shipped 8 working days later after ordering.
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | C3460 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__3__4O__6 = 442.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 470-37-1 |
| Reaxys Registry Number | 64587 |
| PubChem Substance ID | 354335510 |
| MDL Number | MFCD00058625 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 213.0 to 217.0 °C |
| Specific rotation [a]20/D | -3.0 to -5.0 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 215 °C |
| Specific Rotation | -36° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 295(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P284 : Wear respiratory protection. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | EI2955000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
Application
Cinobufagine: An Antitumor Component of Cinobufacini, a Chinese Traditional Medicine
Cinobufagine (or cinobufagin) is an active component of Cinobufacini (Huachansu), which is a Chinese traditional medicine for various cancers prepared from the skin of the toad Bufo bufo gargarizans Cantor. Pharmacological experiments have demonstrated the antitumor activities of cinobufagine, such as inhibition of cell proliferation, induction of cell differentiation, induction of apoptosis, disruption of the cell cycle, inhibition of cancer angiogenesis, resensitization of cancer cells to chemotherapeutic agents, and regulation of the immune response. (The product is for research purpose only.)
References
- Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells
- Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells
- Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor (a review)
- Simultaneous determination of bufadienolides in the traditional Chinese medicine preparation, Liu-Shen-Wan, by liquid chromatography
- Determination of resibufogenin and cinobufagin in heart-protecting musk pill by HPLC
PubMed Literature
Articles/Brochures
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