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CAS RN: 15663-27-1 | Product Number: D3371

cis-Diammineplatinum(II) Dichloride


Purity:
Synonyms:
  • Cisplatin
  • cis-Diamminedichloroplatinum(II)
  • cis-Platinum(II) Diammine Dichloride
Documents:
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Product Number D3371
Molecular Formula / Molecular Weight H__6Cl__2N__2Pt = 300.05  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image)
CAS RN 15663-27-1
PubChem Substance ID 87558796
Merck Index (14) 2317
Specifications
Appearance Light orange to Yellow to Green powder to crystal
Elemental analysis(Nitrogen) 8.90 to 9.80 %
Properties (reference)
Melting Point 270 °C
Solubility in water Practically insoluble
Degree of solubility in water 2,530 mg/l   25 °C
Solubility (soluble in) Dimethylformamide
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H340 : May cause genetic defects.
H350 : May cause cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# TP2450000
Transport Information:
UN Number UN3288
Class 6.1
Packing Group II
Application
Platinum Coordination Complexes as Antitumor Agents

D3371

The development of platinum coordination complexes as antitumor agents began in the 1960s, and the highest antitumor activity was exhibited by cisplatin, approved by FDA in 1978. Improved versions carboplatin [C2043] and oxaliplatin [O0372] were developed to avoid the serious side effects and the problem with resistance associated with the use of cisplatin.1-5)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)

References


Application
Reagent for renal failure model

References


Application
Reagent for nausea or vomiting model

References


Application
Reviews on the Biochemical Mechanisms of Action of Cisplatin

References


PubMed Literature


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