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CAS RN: 761440-16-8 | Product Number: D5068
2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
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Purity: >97.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
¥1,800
|
14 | 8 | 5 | |
| 1G |
¥4,400
|
9 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D5068 |
Purity / Analysis Method 
|
>97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__3H__1__3Cl__2N__3O__2S = 346.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 761440-16-8 |
| Reaxys Registry Number | 12052746 |
| PubChem Substance ID | 354333960 |
| MDL Number | MFCD12827956 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
GHS
Related Laws:
Transport Information:
Application
A Synthetic Intermediate of Anaplastic Lymphoma Kinase (ALK) Inhibitors
This compound is used as a synthetic intermediate of anaplastic lymphoma kinase (ALK) inhibitors which have been reported their potential antitumor activities.
References
- Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
- Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
- Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor
- Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases
PubMed Literature
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