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CAS RN: 379-79-3 | Product Number: E0019
Ergotamine Tartrate
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Purity: >98.0%(T)(HPLC)
Specific Narcotic or Psychotropic Raw Material
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
¥7,500
|
4 | 5 | 10 | |
| 1G |
¥26,300
|
13 | It can be shipped from Saitama warehouse on the same day* | It can be shipped in about 3-4 weeks after ordering |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | E0019 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6__6H__7__0N__1__0O__1__0·C__4H__6O__6 = 1,313.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 379-79-3 |
| Merck Index (14) | 3661 |
| MDL Number | MFCD00069654 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | -155.0 to -167.0 deg(C=0.7, JP Method) |
| Solubility in Acetic acid | almost transparency |
| Drying loss | max. 5.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 203 °C |
| Specific Rotation | -160° (C=0.7,JP Method) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P361 + P364 : Take off immediately all contaminated clothing and wash it before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| Narcotics and Psychotropics Control Law | Specific Narcotic or Psychotropic Raw Material |
| RTECS# | KE8225000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
Application
Efflux pump research
Ergotamine has been reported to display no direct antibacterial activity, but in combination with norfloxacin (N0817), cause a 4-fold reduction in norfloxacin MIC (minimum inhibitory concentration) against a resistant strain.1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- Phytochemicals for Bacterial Resistance – Strengths, Weaknesses and Opportunities
- Ergotamine and dihydroergotamine: history, pharmacology, and efficacy (a review)
- Ergotamine tartrate (a review of ergotamine tartrate tartrate including its physical properties, production and synthesis, metabolism, and methods of analysis)
- Determination of ergotamine tartarate and cyclizine hydrochloride in pharmaceutical tablets by reverse phase HPLC
Application
Ergotamine tartrate: A Naturally Occurring Ergot Alkaloid Acting as an Agonist at the 5-HT1 Receptors
Ergotamine tartrate is a naturally occurring ergot alkaloid produced by the ergot fungus Claviceps purpurea. It has been reported that ergotamine tartrate binds and acts as an agonist at the 5-HT1 receptors located on intracranial blood vessels, similar to the antimigraine triptans. Ergotamine has also agonist activity at several other receptors, including α1-adrenoceptors and dopamine D2 receptors. Dihydroergotamine mesylate [D2633] is a derivative of ergotamine. In clinical, ergotamine tartrate have been widely and effectively used in the treatment of migraine. (The product is for research purpose only.)
References
PubMed Literature
Product Articles
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Safety Data Sheet (SDS)
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Specifications
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