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CAS RN: 163222-33-1 | Product Number: E1449

Ezetimibe


Purity: >95.0%(T)
Synonyms:
  • (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
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Product Number E1449
Purity / Analysis Method >95.0%(T)
Molecular Formula / Molecular Weight C__2__4H__2__1F__2NO__3 = 409.43 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 163222-33-1
Reaxys Registry Number 7981967
PubChem Substance ID 468591792
MDL Number

MFCD00937872

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Volumetric Analysis) min. 95.0 %
Melting point 162.0 to 166.0 °C
Specific rotation -20.0 to -30.0 deg(C=3, Methanol)
Properties (reference)
Melting Point 163 °C
Maximum Absorption Wavelength 285(CH3CN) nm
Solubility in water Insoluble
Degree of solubility in water 4.4 mg/l   25 °C
Solubility (soluble in) Methanol,Ethanol
GHS
Related Laws:
RTECS# CM4554000
Transport Information:
Application
Ezetimibe: A Potent Inhibitor of Cholesterol Intestinal Absorption

Ezetimibe (SCH 58235) is in a class of lipid-lowering agents that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. It has been reported that ezetimibe reduces the small intestinal enterocyte uptake and absorption of cholesterol by binding to a cholesterol transporter Niemann-Pick C1-Like 1 (NPC1L1) which is involved in the intestinal uptake of cholesterol and phytosterols, and keeps cholesterol in the intestinal lumen for excretion. (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
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