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CAS RN: 3778-73-2 | Product Number: I0713
Ifosfamide
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Purity: >95.0%(GC)(T)
Synonyms:
- N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-Oxide
- 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]-1,3,2-oxazaphosphinane 2-Oxide
- Isophosphamide
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
¥18,800
|
It can be shipped in about 2-3 business days after ordering | ≥40 | Contact Us |
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | I0713 |
Purity / Analysis Method 
|
>95.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__7H__1__5Cl__2N__2O__2P = 261.08 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3778-73-2 |
| Reaxys Registry Number | 5802893 |
| PubChem Substance ID | 468592053 |
| Merck Index (14) | 4896 |
| MDL Number | MFCD00057374 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 44.0 to 50.0 °C |
| Specific rotation | -1.0 to +1.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 48 °C |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | RP6050000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
Application
Ifosfamide: An Oxazophosphorine Antitumor Alkylating Agent
Ifosfamide is an oxazaphosphorine alkylating agent with a broad spectrum of antineoplastic activity. It is a prodrug that requires metabolic activation by hepatic cytochrome P450 isoenzymes to exert its cytotoxic activity. The exact mechanism of action of ifosfamide has not been determined, but among various metabolites, isophosphoramide mustard probably represents the most important cytotoxic compound able to produce irreparable cross-links between DNA strands caused by alkylation by the isophosphoramide mustard at guanine N-7 positions. In addition, mesna [M0913] is often used as a prophylactic agent for side effects of oxazophosphorine antitumor alkylating agents such as cyclophosphamide [C2236] and ifosfamide. (The product is for research purpose only.)
References
- Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer.
- Pharmacology of ifosfamide (a review)
- Simultaneous determination of cyclophosphamide, ifosfamide, doxorubicin, epirubicin and daunorubicin in human urine using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry: bioanalytical method validation
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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