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CAS RN: 74103-07-4 | Product Number: K0053

Ketorolac Tromethamine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Ketorolac Tris Salt
  • (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic Acid Tris Salt
Documents:
1G
¥5,700
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5G
¥20,800
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Product Number K0053
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__3NO__3·C__4H__1__1NO__3 = 376.41  
Physical State (20 deg.C) Solid
CAS RN 74103-07-4
Related CAS RN 74103-06-3
Reaxys Registry Number 6463165
PubChem Substance ID 253661330
Merck Index (14) 5306
MDL Number

MFCD00887595

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 167 °C
Maximum Absorption Wavelength 322(MeOH) nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# UY7759900
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
Application
Ketorolac Tromethamine: A Non-Selective Cyclooxygenase (COX) Inhibitor with Strong Analgesic Activity

Ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity. Ketorolac is a non-selective cyclooxygenase (COX) inhibitor. Thus, it reduces prostaglandin synthesis. Ketorolac is the racemic mixture of (-)-S and (+)-R enantiomers. Most of its analgesic and COX inhibitory activity is retained in the S-isomer. Besides, some formulations for controlled release of ketorolac tromethamine have been reported. Ketorolac and its metabolites are excreted primarily by the kidneys. For your reference, [B4934] is used as a synthetic intermediate of ketorolac. (The product is for research purpose only.)

References


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