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CAS RN: 1115-70-4 | Product Number: M2009

Metformin Hydrochloride

Purity: >98.0%(T)(HPLC)
Chemical Substance Law (ENCS):   2-2883
  • 1,1-Dimethylbiguanide Hydrochloride
≥40  10   ≥40 
≥40  19   ≥40 
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Product Number M2009
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__4H__1__1N__5·HCl = 165.63 
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 1115-70-4
Related CAS RN 657-24-9
Reaxys Registry Number 3626131
PubChem Substance ID 160871506
Merck Index (14) 5938
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 219.0 to 223.0 °C
Properties (reference)
Melting Point 221 °C
Maximum Absorption Wavelength 233(H2O) nm
Solubility in water Completely soluble
Solubility (very slightly) Ethanol
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H320 : Causes eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
Chemical Substance Law (ENCS) 2-2883
RTECS# DU1800000
Transport Information:
Mitophagy research


Activation of AMP-activated Protein Kinase (AMPK) by Metformin

Metformin hydrochloride, an oral biguanide antihyperglycemic agent, is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin lowers the blood glucose concentration without causing hypoglycemia, but the precise mechanism of action of metformin is not fully understood. However, it has been reported that metformin activates adenosine 5’-monophosphate-activated protein kinase (AMPK, a major cellular regulator of lipid and glucose metabolism) in hepatocytes. As a result, hepatic glucose production is decreased and skeletal myocyte glucose uptake is increased. Recently, some combination agents with other anti-diabetes agents (eg. sulfonylureas and thiazolidinediones) have been developed to treat type-2 diabetes. (The product is for research purpose only.)


Metformin Shows an Antidiabetic Effect by Regulating Lipid Metabolism via AMPK-ACC Pathway



PubMed Literature

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