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CAS RN: 6964-62-1 | Product Number: M2390

NSC 66811


Purity: >98.0%(GC)
Synonyms:
  • 8-Hydroxy-2-methyl-7-[phenyl(phenylamino)methyl]quinoline
  • 2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol
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25MG
¥15,700
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Product Number M2390
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__2__3H__2__0N__2O = 340.43  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 6964-62-1
Reaxys Registry Number 303275
PubChem Substance ID 354335381
MDL Number

MFCD08823776

Specifications
Appearance White to Amber to Dark green powder to crystal
Purity(GC) min. 98.0 %
Purity(Nonaqueous Titration) min. 96.0 %
Melting point 143.0 to 147.0 °C
Properties (reference)
Melting Point 145 °C
Maximum Absorption Wavelength 250(EtOH) nm
GHS
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Application
NSC 66811: An Inhibitor of MDM2-P53 Protein-Protein Interaction

NSC 66811 is an inhibitor of the murine double minute 2 (MDM2)-p53 protein-protein interaction. MDM2 protein is an oncogenic one, and p53 is a tumor suppressor protein. Reportedly, the p53 is inactivated in many cancer cells through mutations or by its interaction with MDM2 protein. Therefore, recently it is considered that blocking the MDM2-p53 interaction is a novel anticancer strategy. (The product is for research purpose only.)

References


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