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CAS RN: 73590-58-6 | Product Number: O0359

Omeprazole


Purity: >98.0%(T)(HPLC)
Synonyms:
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Product Number O0359
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__9N__3O__3S = 345.42  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
CAS RN 73590-58-6
Reaxys Registry Number 3628192
PubChem Substance ID 87560875
Merck Index (14) 6845
MDL Number

MFCD00083192

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 151 °C(dec.)
Solubility in water Insoluble
Solubility (very soluble in) Dimethylformamide,Chloroform
Solubility (slightly sol. in) Ethanol,Methanol
Solubility (insoluble in) Ether
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
RTECS# DD9087000
Transport Information:
Application
最初に開発されたプロトンポンプ阻害剤 (PPI),オメプラゾール

Omeprazole is the first proton pump inhibitor (PPI) that reduces gastric acid secretion. PPIs, such as omeprazole, lansoprazole [L0233], rabeprazole [R0115] and pantoprazole, are metabolized by cytochrome P 450 isoenzymes, 2C19 (CYP2C19) in the liver. The active (S)-enantiomer of omeprazole is esomeprazole. In additon, combinations of omeprazole as a PPI, amoxicillin [A2099], clarithromycin [C2220] and metronidazole [M0924] or another antibiotic have been reported to be effective in the treatment of Helicobacter pylori infection. Omeprazole is synthesized by the oxidation of omeprazole sulfide [O0437].

References


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