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CAS RN: 145-13-1 | Product Number: P0786
Pregnenolone
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Purity: >98.0%(GC)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
¥4,600
|
28 | 8 | 30 | |
| 25G |
¥11,800
|
17 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P0786 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__1H__3__2O__2 = 316.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 145-13-1 |
| Reaxys Registry Number | 2059026 |
| PubChem Substance ID | 87574922 |
| SDBS (AIST Spectral DB) | 4949 |
| Merck Index (14) | 7733 |
| MDL Number | MFCD00003628 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 187.0 to 192.0 °C |
| Specific rotation [a]20/D | +26.0 to +29.0 deg(C=1,EtOH) |
| Solubility in hot Chloroform | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 190 °C |
| Specific Rotation | 28° (C=1,EtOH) |
| Solubility (soluble in) | Chloroform |
GHS
Related Laws:
| RTECS# | TU5560700 |
Transport Information:
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Pregnenolone has been reported to act as a germinant for Clostridium sordellii spores (EC50 = 9.3 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
文献
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
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