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CAS RN: 171228-49-2 | Product Number: P2477
Posaconazole
×
Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
¥11,400
|
7 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 50MG |
¥34,400
|
≥60 | 3 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | P2477 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__7H__4__2F__2N__8O__4 = 700.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 171228-49-2 |
| Reaxys Registry Number | 8379448 |
| PubChem Substance ID | 354335523 |
| Merck Index (14) | 7602 |
| MDL Number | MFCD00941162 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 167.0 to 171.0 °C |
| Specific rotation [a]20 | -24.0 to -28.0 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 169 °C |
| Specific Rotation | -26° (C=1,CHCl3) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | XZ5481020 |
Transport Information:
Application
Posaconazole: An Triazole Antifungal Agent with Broad-Spectrum Activity
Posaconazole (SCH 56592), an triazole antifungal agent with broad-spectrum activity, appears to inhibit ergosterol synthesis of fungi by inhibiting the enzyme lanosterol 14 α-demethylase. Inhibition of this enzyme’s activity by posaconazole results in decreased amounts of ergosterol, a constituent of fungal cell membranes. Especially, posaconazole has broader spectrum of activity than other available antifungals. Posaconazole has even activity against Aspergillus fumigatus and Candida albicans refractory to other triazole antifungal agents, such as itraconazole [I0732] or fluconazole [F0677]. (The product is for research purpose only.)
References
- Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts
- Three-dimensional models of wild-type and mutated forms of cytochrome P450 14α-sterol demethylasesfrom Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding
- Posaconazole: A broad-spectrum triazole antifungal (a review)
- Posaconazole: Clinical pharmacology and potential for management of fungal infections (a review)
- Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid chromatography with ultra-violet detection
- Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspofungin
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