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CAS RN: 61413-54-5 | Product Number: R0110


Purity: >98.0%(HPLC)
  • 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
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Product Number R0110
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__1NO__3 = 275.35  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Heat Sensitive
Packaging and Container 50MG-Glass Bottle with Plastic Insert (View image)
CAS RN 61413-54-5
Reaxys Registry Number 1588548
PubChem Substance ID 253659657
Merck Index (14) 8251
MDL Number


Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 130.0 to 134.0 °C
Properties (reference)
Melting Point 132 °C
Related Laws:
RTECS# UY5749237
Transport Information:
Rolipram: A Selective PDE4 Inhibitor

Rolipram is a selective inhibitor of phosphodiesterases 4 (PDE4s) originally developed as an antidepressant agent in 1990s, but fell out of favor because of its undesirable gastrointestinal side effects. Nowadays, rolipram continues to be used in research as a PDE4 inhibitor. PDE4s are responsible for hydrolysis of the cyclic nucleotides cAMP [A2381] and cGMP to 5’-AMP [A0158] and 5’-GMP [G0338], particularly in nerve and immune cells. The inhibition of PDE4s by rolipram induces the elevation of intracellular cAMP concentration. Consequences rolipram-induced elevation of cAMP suppress expression of proinflammatory cytokines and other mediators of inflammation. Rolipram has been reported as a drug for the treatment of autoimmune diseases, Alzheimer's disease, cognitive enhancement, and respiratory diseases like asthma and COPD. Rolipram is a racemic compound, and (R)-rolipram [R0182] is more potent than (S)-rolipram [R0183] as a PDE4 inhibitor. (The product is for research purpose only.)


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