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CAS RN: 80214-83-1 | Product Number: R0164
Roxithromycin
×
Purity: >95.0%(HPLC)
Synonyms:
- Erythromycin 9-[O-(2-Methoxyethoxy)methyloxime]
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
¥7,100
|
3 | 10 | 1 | |
| 25G |
¥19,300
|
15 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | R0164 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__1H__7__6N__2O__1__5 = 837.06 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 80214-83-1 |
| Reaxys Registry Number | 5900029 |
| PubChem Substance ID | 253661176 |
| Merck Index (14) | 8276 |
| MDL Number | MFCD00214389 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Elemental analysis(Nitrogen) | 3.10 to 3.60 % |
| Specific rotation [a]20/D | -93.0 to -96.0 deg(C=1, Acetone)(calcd.on anh.substance) |
| Water | max. 3.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 120 °C |
| Specific Rotation | -95° (C=1,Acetone) |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | KF4990000 |
Transport Information:
Application
Roxithromycin: An Acid-Stable and Enteric Absorbent Semi-Synthetic Macrolide Antibiotic
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Roxithromycin (abbrev: RXM) is chemically synthesized from erythromycin [E0751] to create a more acid-stable antimicrobial and prevents the degradation of the erythromycin base to the hemiketal intermediate. RXM has an in vitro antibacterial profile similar to that of erythromycin. RXM has a pharmacokinetic profile that is characterized by excellent enteric absorption within macrolide antibiotics achieving high concentrations in most tissues and body fluids. In addition, RXM immunomodulatory activities have reported.
References
- A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy
- The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin (a review)
- Roxithromycin: review of its antimicrobial activity
- Analysis of macrolide antibiotics (a review)
- Determination of erythromycin, clarithromycin, roxithromycin, and azithromycin in plasma by high-performance liquidchromatography with amperometric detection
- Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin
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