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CAS RN: 85416-75-7 | Product Number: R0182


Purity: >98.0%(HPLC)
  • (R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
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Product Number R0182
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__6H__2__1NO__3 = 275.35 
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 85416-75-7
Reaxys Registry Number 5442919
PubChem Substance ID 354333406
MDL Number


Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Optical purity(LC) min. 98.0 ee%
Elemental analysis(Nitrogen) 4.50 to 5.50 %
Melting point 132.0 to 136.0 °C
Specific rotation [a]20/D -29.0 to -34.0 deg(C=0.5, MeOH)
Properties (reference)
Melting Point 134 °C
Specific Rotation -32° (C=0.5,MeOH)
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(R)-(-)-Rolipram: The Active Enantiomer of Rolipram, PDE4 Inhibitor

(R)-(-)-Rolipram is the active enantiomer of rolipram [R0110] which is a selective inhibitor of phosphodiesterases 4 (PDE4s). It has been reported that (R)-(-)-rolipram is approximately 3 times more potent than (S)-(+)-rolipram [R0183] against PDE4. In 2015, Kobayashi et al. have been reported a new multistep continuous-flow synthesis of (R)- and (S)-rolipram using only columns packed with heterogeneous catalysts. (The product is for research purpose only.)


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