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CAS RN: 738-70-5 | Product Number: T2286
Trimethoprim
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
¥8,200
|
5 | 16 | ≥80 | |
| 100G |
¥13,800
|
3 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 500G |
¥34,600
|
6 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
if you need further information.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T2286 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__8N__4O__3 = 290.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 738-70-5 |
| Reaxys Registry Number | 625127 |
| PubChem Substance ID | 87558288 |
| Merck Index (14) | 9709 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 199.0 to 205.0 °C |
| Solubility in hot Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 202 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 400 mg/l 25 °C |
| Solubility (slightly sol. in) | Methanol, Chloroform |
| Solubility (insoluble in) | Ether, Benzene |
GHS
Related Laws:
| RTECS# | UV8225000 |
Transport Information:
Application
Efflux pump research
Trimethoprim has been reported to inhibit efflux pump in Gram-negative bacteria thereby having the synergy with ciprofloxacin [C2510].1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria
- Trimethoprim: mechanisms of action, antimicrobial activity, bacterial resistance, pharmacokinetics, adverse reactions, and therapeutic indications (a review)
- Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections
- Trimethoprim/sulfonamide combinations in the horse: A review
- Trimethoprim and sulfonamide resistance (a review)
- Evaluation of the novel combination of high-dose daptomycin plus trimethoprim-sulfamethoxazole against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus using an in vitro pharmacokinetic/pharmacodynamic model of simulated endocardial vegetations
- Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry
Application
Trimethoprim: A Synthetic Antibiotic Agent Inhibiting Dihydrofolate Reductase
Trimethoprim, a synthetic antibiotic agent, exerts antimicrobial activity by blocking the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. In addition, some combination agents with the other antimicrobials (e.g.: sulphamethoxazole [S0361], daptomycin [D4229] and polymyxin B [P1923]) are widely used for the treatment of infections including MRSA infection. (The product is for research purpose only.)
References
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