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CAS RN: 52-24-4 | Product Number: T4184
Thiotepa
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Purity: >95.0%(HPLC)
Chemical Substance Law (ENCS):
9-863
Synonyms:
- Thio-TEPA
- Tri(aziridin-1-yl)phosphine Sulfide
- 1-[Bis(1-aziridinyl)phosphorothioyl]aziridine
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
¥38,000
|
16 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T4184 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__1__2N__3PS = 189.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 52-24-4 |
| Reaxys Registry Number | 145978 |
| MDL Number | MFCD00145452 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 52.0 to 56.0 °C |
| Water | max. 2.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 54 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H360 : May damage fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| Chemical Substance Law (ENCS) |
9-863 |
| RTECS# | SZ2975000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
Application
Thiotepa: An Alkylating Cytotoxic Agent with a Broad Spectrum of Antitumor Activity
Thiotepa (ThioTEPA) is a trifunctional alkylating cytotoxic agent with a broad spectrum of antitumor activity. It is thought to inhibit tumor growth by inhibiting DNA synthesis.1) The major DNA bond cleavages are initiated by alkylation of guanine and adenine at the N-7 position, which breaks the bond between the purine base and the sugar, releasing alkylated guanines and adenines.2) (The product is for research purpose only.)
References
- 1) Chemistry, pharmacology and pharmacokinetics of N,N',N" - triethylenethiophosphoramide triethylenethiophosphoramide (ThioTEPA) (a review)
- 2) Density Functional Theory Investigation of the Binding of ThioTEPA to Purine Bases: Thermodynamics and Bond Evolution Theory Analysis
Product Documents (Note: Some products will not have analytical charts available.)
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