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Printed Magazine "TCIMAIL" > TCIMAIL Back Numbers 2018 >

AMP-Activated Protein Kinase (AMPK) Inhibitor

No.176(January 2018)
D5394
Dorsomorphin (1)
Dorsomorphin (1) is a potent inhibitor of AMP-activated protein kinase (AMPK).1) AMPK is inhibited by 1 with
Ki = 109 nM. However, 1 does not significantly inhibit structurally related kinases, including spleen tyrosine kinase (SYK), zeta-chain-associated protein kinase (ZAPK), protein kinase A (PKA), protein kinase Cθ (PKCθ), and Janus kinase (JAK).
Additionally, 1 inhibits bone morphogenetic protein (BMP) signaling.2) 1 promotes self-renewal of human embryonic stem cells (hESCs).3) Interestingly, 1 can support stem cell self-renewal over the long term (five or more passes).

This product is for research purpose only.

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