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CAS RN: 5508-58-7 | Product Number: A2459

Andrographolide


Purity: >98.0%(HPLC)
Synonyms:
Documents:
1G
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5G
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Product Number A2459
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__0H__3__0O__5 = 350.46  
Physical State (20 deg.C) Solid
CAS RN 5508-58-7
Reaxys Registry Number 5609598
PubChem Substance ID 253659551
Merck Index (14) 633
MDL Number

MFCD07778082

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 229.0 to 235.0 °C
Specific rotation [a]20/D -124 to -129 deg(C=1.5, AcOH)
Properties (reference)
Melting Point 231 °C
Specific Rotation -126° (C=1.5,AcOH)
Maximum Absorption Wavelength 223(MeOH) nm
GHS
Related Laws:
RTECS# LU3490750
Transport Information:
H.S.code* 2932.20-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Studies on the Pharmacological Activity of Andrographolide as a NF-κB Activation Inhibitor and an Anti-inflammatory Agent
References

Immunostimulant agents from Andrographis paniculata

A. Puri, R. Saxena, R. P. Saxena, K. C. Saxena, V. Srivastava, J. S. Tandon, J. Nat. Prod. 1993, 56, 995.

Andrographolide Attenuates Inflammation by Inhibition of NF-κB Activation through Covalent Modification of Reduced Cysteine 62 of p50

Y.-F. Xia, B.-Q. Ye, Y.-D. Li, J.-G. Wang, X.-J. He, X. Lin, X. Yao, D. Ma, A. Slungaard, R. P. Hebbel, N. S. Key, J.-G. Geng, J. Immunol. 2004, 173, 4207.

Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti- inflammatory effect

Y.-C. Shen, C.-F. Chen, W.-F. Chiou, Br. J. Pharmacol. 2002, 135, 399.

In vitro and in vivo anti-inflammatory effects of andrographolide

A. A. Abu-Ghefreh, H. Canatan, C. I. Ezeamuzie, Int. Immunopharmacol. 2009, 9, 313.

Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata

S. Rajagopal, R. A. Kumar, D. S. Deevi, C. Satyanarayana, R. Rajagopalan, J. Exp. Ther. Oncol. 2003, 3, 147.


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