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CAS RN: 50-02-2 | Product Number: D1961

Dexamethasone


Purity: >99.0%(HPLC)
Synonyms:
Documents:
1G
₩ 132,800
≥20  ≥20 
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Product Number D1961
Purity / Analysis Method >99.0%(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__9FO__5 = 392.47  
Physical State (20 deg.C) Solid
CAS RN 50-02-2
Reaxys Registry Number 3176546
PubChem Substance ID 87568418
SDBS (AIST Spectral DB) 15273
Merck Index (14) 2943
MDL Number

MFCD00064136

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 99.0 area%
Specific rotation [a]20/D +72.0 to +80.0 deg(C=1, Dioxane)
Properties (reference)
Melting Point 264 °C
Specific Rotation 76° (C=1,Dioxane)
Solubility in water Insoluble
Degree of solubility in water 100 mg/l   25 °C
Solubility (soluble in) Chloroform,Ethanol,Ether,Acetone
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# TU3980000
Transport Information:
H.S.code* 2937.29-000
*This code is applied to the products when TCI exports from Japan and not for import in your country.
Application
Dexamethasone: A Synthetic Glucocorticoid with Potent Anti-Inflammatory Activities

Dexamethasone is a synthetic glucocorticoid compound with potent anti-inflammatory activities. Dexamethasone binds more powerfully to the glucocorticoid receptor than cortisol dose. Usually, glucocorticoid receptors (GRs) bind to heat shock protein 90 (HSP90). For the receptors, dexamethasone binding promotes dissociation of the receptor from HSP90 and conversion of the receptor to the DNA (glucocorticoid responsive element, GRE)-binding state, resulting in inducing change in regulating mRNA expression that lead to anti-inflammatory reactions. (The product is for research purpose only.)

References


Application
iPS cell generation boosting compounds

Reference


PubMed Literature


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