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CAS RN: 520-34-3 | Product Number: D4441
Diosmetin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3',5,7-Trihydroxy-4'-methoxyflavone
- Luteolin 4'-Methyl Ether
- 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
₩126,800
|
27 | 10 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | D4441 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__2O__6 = 300.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 520-34-3 |
| Reaxys Registry Number | 294492 |
| PubChem Substance ID | 468591266 |
| MDL Number | MFCD00017425 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 260.0 to 264.0 °C |
Properties (reference)
| Melting Point | 262 °C |
| Maximum Absorption Wavelength | 348 nm (MeOH) |
| Solubility (soluble in) | Acetone, Chloroform, dichloromethane |
GHS
Related Laws:
| RTECS# | DJ2984400 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Diosmetin: A Flavonoid with Diverse Biological Activities
Diosmetin, the aglycon part of diosmin [D3908], is a flavonoid that has been found in citrus fruits. It has been reported to exert diverse biological activities such as anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-tumor activities.1-4) In addition, it inhibits the cytochrome P450 isoforms CYPA1 and CYP1B1.5) (The product is for research purpose only.)
References
- 1) Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation
- 2) Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
- 3) A review on pharmacological and analytical aspects of diosmetin: A concise report
- 4) Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer
- 5) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids
- 6) Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study
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