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CAS RN: 190728-25-7 | Product Number: D5070
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
![Chemical Structure of 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline](/medias/D5070.jpg?context=bWFzdGVyfHJvb3R8Njc1NzB8aW1hZ2UvanBlZ3xhRGczTDJnME1TODRPVEl4TkRZNU1UVTNOREEyTDBRMU1EY3dMbXB3Wnd8ZTNmNTUxNTdhZTNhNGQ2ZWE3NmE3ZDlhYjZmNjgyZTI4YWRlZGQ2MjAxOGNiNzczNWI3YTc2YjAwZTc4YzE4Nw "4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline")
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![4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline")
Purity:
Synonyms:
- 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
₩56,600
|
2 | 3 | It can be shipped in about 2 weeks after ordering | |
| 1G |
₩218,400
|
2 | 12 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | D5070 |
| Molecular Formula / Molecular Weight | C__1__7H__1__6N__2O__3 = 296.33 |
| Physical State (20 deg.C) | Solid |
Storage Temperature 
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 190728-25-7 |
| Reaxys Registry Number | 1490304 |
| PubChem Substance ID | 354334606 |
| MDL Number | MFCD19685633 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 211.0 to 215.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 214 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.49-000 |
Application
A Synthetic Intermediate of VEGFR-2 Tyrosine Kinase Inhibitors and PDGFR Tyrosine Kinase Inhibitors
This reagent has been used for the synthesis of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitors such as cabozantinib [CAS: 849217-68-1],1-3) and platelet-derived growth factor receptor (PDGFR) tyrosine kinase inhibitors.4,5)
References
- 1)Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure-Activity Relationships, and Antitumor Activities of N-Phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas
- 2)N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors
- 3)Degradation kinetics study of cabozantinib by a novel stability-indicating LC method and identification of its major degradation products by LC/TOF-MS and LC-MS/MS
- 4)Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase
- 5)Identification of Potent and Selective Inhibitors of PDGF Receptor Autophosphorylation
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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