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CAS RN: 436-77-1 | Product Number: F1173
Fangchinoline
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Purity: >97.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
₩220,400
|
14 | 17 | It can be shipped in about 3-4 weeks after ordering | |
| 100MG |
₩764,400
|
5 | 20 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | F1173 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__7H__4__0N__2O__6 = 608.74 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 436-77-1 |
| Reaxys Registry Number | 78975 |
| PubChem Substance ID | 468591833 |
| MDL Number | MFCD00221726 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 4.00 to 5.00 % |
Properties (reference)
| Melting Point | 238 °C(dec.) |
| Maximum Absorption Wavelength | 283 nm (EtOH) |
GHS
Related Laws:
| RTECS# | DR9280000 |
Transport Information:
| H.S.code* | 2939.79-000 |
Application
Fangchinoline: An Alkaloid with Diverse Pharmacological Effects Including Significant Antitumor Activities
Fangchinoline and tetrandrine [T3321] are the major alkaloids from Stephenia tetrandra S Moore which is a plant indigenous to main land of China that has long been used as a Chinese herb. Stephenia tetrandra S Moore is traditionally used as analgesic, antirheumatic, and antihypertensive drug.1,2) Recently, fangchinoline has been found to exhibit diverse pharmacological effects including significant antitumor activities.3-5) (The product is for research purpose only.)
References
- 1) Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat
- 2) Anti-inflammatory effects of fangchinoline and tetrandrine
- 3) Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft
- 4) Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
- 5) Molecular targets modulated by fangchinoline in tumor cells and preclinical models (a review)
- 6) Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry
- 7) Determination of tetrandrine and fangchinoline in plasma samples using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography
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