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CAS RN: 53-86-1 | Product Number: I0655
Indomethacin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic Acid
- Indometacin
Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25G |
₩ 70,400
|
11 | ≥20 |
| 100G |
₩ 200,000
|
1 | 18 |
| 500G |
₩ 563,200
|
6 | 16 |
* Please contact our distributor of SEJIN CI
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination.
* SEJIN CI (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
* SEJIN CI (Phone: 02-2655-2480 / email: sales@sejinci.co.kr)
| Product Number | I0655 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__6ClNO__4 = 357.79 |
| Physical State (20 deg.C) | Solid |
| Condition to Avoid | Light Sensitive |
| CAS RN | 53-86-1 |
| Reaxys Registry Number | 497341 |
| PubChem Substance ID | 87561687 |
| Merck Index (14) | 4968 |
| MDL Number | MFCD00057095 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 158.0 to 162.0 °C |
| Solubility in hot Methanol | almost transparency |
Properties (reference)
| Melting Point | 160 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.937 mg/l 25 °C |
| Solubility (soluble in) | Methanol,Ether,Acetone,Chloroform,Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NL3500000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | I |
| H.S.code* | 2933.99-000 |
Application
Reagent for gastropathy (gastric mucosal injury) model
References
- Oxidative stress involvement and gene expression in indomethacin-induced gastropathy
- Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury
- Y. Naito, T. Yoshikawa, N. Yoshida, M. Kondo, Dig. Dis. Sci. 1998, 43, 30S.
- Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
Application
Studies on Inhibition of Cyclooxygenase (COX)
References
- A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
- NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2
- Inducible cyclooxygenase may have anti-inflammatory properties
- Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
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