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CAS RN: 1432597-26-6 | Product Number: L0347
LDN-212854
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Purity: >95.0%(HPLC)
Synonyms:
- 5-[6-[4-(Piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
₩263,300
|
9 | 0 | Contact Us | |
| 25MG |
₩838,500
|
29 | 4 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | L0347 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__5H__2__2N__6 = 406.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 1432597-26-6 |
| Reaxys Registry Number | 23637228 |
| MDL Number | MFCD28099808 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 13.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 216 °C(dec.) |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
LDN-212854: A Selective Activin Receptor-Like Kinase-2 (ALK2) Inhibitor
LDN-212854 is a selective inhibitor of activin receptor-like kinase-2 (ALK2) which is a member of the type I BMP receptors. BMP plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases, and BMP signaling regulates many different biological processes, including cell growth, differentiation, and embryogenesis.
References
- Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor
- Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe
- Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2
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