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CAS RN: 345627-80-7 | Product Number: N1274
SNS-032
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- BMS 387032
- N-[5-[[[5-(tert-Butyl)oxazol-2-yl]methyl]thio]thiazol-2-yl]piperidine-4-carboxamide
- SNS 032
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
₩267,200
|
10 | 30 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | N1274 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__7H__2__4N__4O__2S__2 = 380.53 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 345627-80-7 |
| Reaxys Registry Number | 9654646 |
| MDL Number | MFCD09833875 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 170.0 to 174.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 172 °C |
GHS
Related Laws:
| RTECS# | TM6071000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
SNS-032: A Cyclin-Dependent Kinase (CDK) Inhibitor
Cyclins and cyclin-dependent kinases (CDKs) are a key component of the regulatory proteins that control the cell cycle. CDK plays a critical role in regulating the cell cycle transition and is primarily involved in the pathogenesis of cancer. SNS-032 (BMS 387032) is a CDK inhibitor that competes for ATP binding sites on these kinases, thereby reducing tumor growth and inducing cell death. There are reports that SNS-032 inhibits CDK2, CDK7, and CDK9 and leads to growth arrest and apoptosis of tumor cell lines. (The product is for research purpose only.)
References
- N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highlyefficacious and selective antitumor agent
- Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia
- SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples
- Discovery of BMS-387032, a potent cyclin-dependent kinase inhibitor in clinical development (a review)
- Cyclin-dependent kinase modulators and cancer therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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