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CAS RN: 13553-79-2 | Product Number: R0200
Rifamycin S
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Purity: >98.0%(HPLC)
Synonyms:
- 1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩181,400
|
5 | 10 | Contact Us | |
| 5G |
₩633,800
|
25 | 0 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | R0200 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__7H__4__5NO__1__2 = 695.76 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 13553-79-2 |
| Reaxys Registry Number | 604802 |
| PubChem Substance ID | 354335535 |
| Merck Index (14) | 8217 |
| MDL Number | MFCD06198807 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
| Specific rotation [a]20/D | +451 to +500 deg(C=0.1, methanol) |
Properties (reference)
| Melting Point | 201 °C |
| Specific Rotation | 476° (C=0.1,MeOH) |
| Maximum Absorption Wavelength | 390 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H371 : May cause damage to organs. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
Related Laws:
| RTECS# | KD1925000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Rifamycin S: A "Classic" Rifamycin with Potent Antimicrobial Activity but Poor Tolerability
Rifamycin S belongs to the family of ansamycin antibiotics, rifamycins. Initially, rifamycins were discovered referred to as rifamycin A, B, C, D, E in 1957. Among these, rifamycin B isolated in a pure form. Although its antimicrobial activity was moderate, it was oxidized and hydrolyzed to yield the highly active rifamycin S, a quinone molecular with potent antimicrobial activity but poor tolerability. Rifamycins inhibit DNA-dependent RNA polymerase in susceptible strains of bacteria, including Mycobacterium tuberculosis and Gram-positive bacteria. The rifamycin group includes the "classic" rifamycins as well as active rifamycin derivatives, rifampicin [R0079], rifaximin [R0101] and rifabutin [R0211]. (The product is for research purpose only.)
References
- Correlation of structure and activity in ansamycins: structure, conformation, and interactions of antibiotic rifamycin S
- A comparative study of the redox-cycling of a quinone (rifamycin S) and a quinonimine (rifabutin) antibiotic by rat liver microsomes
- Rifamycin-Mode of Action, Resistance, and Biosynthesis (a review)
- Identification and quantitation of rifamycins by reversed-phase high-performance liquid chromatography
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