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CAS RN: 155141-29-0 | Product Number: R0271
Rosiglitazone Maleate
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 5-[4-[2-[Methyl(2-pyridinyl)amino]ethoxy]benzyl]-1,3-thiazolidine-2,4-dione (2Z)-2-Butenedioate
- 5-[4-[2-[Methyl(pyridin-2-yl)amino]ethoxy]benzyl]thiazolidine-2,4-dione Maleate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
₩120,900
|
≥60 | 0 | Contact Us | |
| 5G |
₩417,300
|
39 | 0 | Contact Us |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | R0271 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__9N__3O__3S·C__4H__4O__4 = 473.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 155141-29-0 |
| Reaxys Registry Number | 7966066 |
| MDL Number | MFCD03427306 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 115.0 to 119.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 117 °C |
GHS
Related Laws:
| RTECS# | XJ5813870 |
Transport Information:
| H.S.code* | 2934.10-000 |
Application
Rosiglitazone Maleate: An Agonist at the Peroxisome Proliferator-Activated Receptor of the Gamma Subtype (PPARγ)
Rosiglitazone maleate and rosiglitazone (free base) [R0106] are agonists at the peroxisome proliferator-activated receptor gamma subtype (PPARγ), a transcriptional regulator. PPAR receptors are found in peripheral tissues that are important for insulin action. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin-responsive genes involved in the control of glucose and lipid metabolism. Therefore, rosiglitazone decreases insulin resistance in peripheral tissues and in the liver, resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Recently, rosiglitazone has been reported to be associated with cardiovascular problems. (The product is for research use only.)
References
- A review of rosiglitazone in type 2 diabetes mellitus (a review)
- Potential remains for PPAR-targeted drugs (a review)
- Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality (a review)
- Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations
Product Documents (Note: Some products will not have analytical charts available.)
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