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CAS RN: 6846-35-1 | Product Number: X0001
Xanthane Hydride
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Purity: >96.0%(HPLC)
Synonyms:
- ADTT
- 5-Amino-3H-1,2,4-dithiazole-3-thione
- 3-Amino-1,2,4-dithiazole-5-thione
- 5-Imino-5H-[1,2,4]dithiazole-3-thiol
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
₩212,600
|
3 | 0 | It can be shipped in about 5-6 months after ordering | |
| 100G |
₩620,100
|
1 | 0 | It can be shipped in about 5-6 months after ordering | |
| 500G |
₩1,509,300
|
1 | 0 | It can be shipped in about 5-6 months after ordering |
* Please contact our distributor of SEJIN CI Co., Ltd.
if you would like to purchase TCI products. The above prices do not include freight cost, customs charge and other charges to the destination. SEJIN CI Co., Ltd. (Phone: 02-2655-2480 / email:
sales@sejinci.co.kr)
* The storage conditions are subject to change without notice.
* The storage conditions are subject to change without notice.
| Product Number | X0001 |
| Purity / Analysis Method | >96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2H__2N__2S__3 = 150.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6846-35-1 |
| Reaxys Registry Number | 112403 |
| PubChem Substance ID | 87577871 |
| SDBS (AIST Spectral DB) | 3701 |
| MDL Number | MFCD00051660 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(with Total Nitrogen) | min. 96.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | JO6500000 |
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Sulfur-Transfer Reagents for Synthesis of Oligonucleotide Phosphorothioates
References
- Nucleic acid therapeutics: basic concepts and recent developments
- 3H-1,2-Benzodithiol-3-one 1,1-dioxide
- Phosphorothioate Oligonucleotides with Low Phosphate Diester Content: Greater than 99.9% Sulfurization Efficiency with “Aged” Solutions of Phenylacetyl Disulfide (PADS)
- Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
Application
Xanthane Hydride: A Sulfur-Transfer Reagent for Synthesis of Oligonucleotide Phosphorothioates
Xanthane hydride (3-amino-1,2,4-dithiazole-5-thione), Beaucage Reagent [B3125] and Bis(phenylacetyl) disulfide [B3623] are used as a sulfur-transfer reagent for synthesis of oligonucleotide phosphorothioates via the phosphoramidite method.1-4) In particular, xanthane hydride has advantages because it does not yield oxidizing substances, carbon disulfide and cyanamide as the additional reaction products.2,3) For DNA/RNA synthesizer, xanthane hydride solution is used, such as 0.02 M solution in acetonitrile/pyridine (9:1),1) or 0.20 M solution in pyridine.4)
References
- 1)Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent
- 2)Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)
- 3)Evidence for the formation of isothiocyanate during sulfurisation of phosphines and phosphites using xanthane hydride
- 4)Synthesis of 5’-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies
PubMed Literature
Documents
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