[6]-Shogaol

Reference

• 6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition
  • D. Nedungadi, A. Binoy, N. Pandurangan, S. Pal, B.G. Nair, N. Mishra, Exp. Cell Res. 2018, 364, 243.


Application
[6]-Shogaol: A Bioactive Component of Heated or Dried Ginger
[6]-Shogaol is a pungent compound that is rarely found in fresh ginger (Zingiber officinalis), but is found in heated or dried ginger. Its precursor before dehydration is [6]-gingerol [G0413], but it has been reported that [6]-shogaol is mainly responsible for the pungent flavor and biological activity of ginger. It has been reported that [6]-shogaol shows various physiological activities such as anticancer, antioxidant, antibacterial, anti-inflammatory, and anti-allergic effects. (The product is for research purpose only.)

References

• Pharmacological studies on ginger. I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol
  • M. Suekawa, A. Ishige, K. Yuasa, K. Sudo, M. Aburada, E. Hosoya, J. Pharm. Dyn. 1984, 7, 836.
• 6-Shogaol induces apoptosis in human colorectal carcinoma cells viaROS production, caspase activation, and GADD 153 expression
  • M.-H. Pan, M.-C. Hsieh, J.-M. Kuo, C.-S. Lai, H. Wu, S. Sang, C.-T. Ho, Mol. Nutr. Food Res. 2008, 52, 527.
• Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol
  • S. Dugasani, M. R. Pichika, V. D. Nadarajah, M. K. Balijepalli, S. Tandra, J. N. Korlakunta, J. Ethnopharmacol. 2010, 127, 515.
• Gingerols and shogaols: Important nutraceutical principles from ginger (a review)
  • R. B. Semwal, D. K. Semwal, S. Combrinck, A. M. Viljoen, Phytochemistry 2015, 117, 554.
• High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages
  • H. A. Schwertner, D. C. Rios, J. Chromatogr. B 2007, 856, 41.