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CAS RN: 1694-92-4 | 제품번호: N0142
2-Nitrobenzenesulfonyl Chloride
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순도/분석 방법: >95.0%(GC)(T)
동의어의:
- o-Ns-Cl
제품문서:
•본 제품의 재고는 일본 본사의 재고입니다. 주문시, 5일안에 실험실까지 도착됩니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
•본건의 원가격은 한국 대리점의 예상 판매가격입니다.자세한 정보가 필요하시면 연락해 주십시오.( SEJIN CI Co., Ltd. (한국총대리점) 전화 : 02-2655-2480 이메일 : sales@sejinci.co.kr)
•보관 조건은 예고없이 변경 될 수 있습니다. 제품 보관 조건의 최신 자료는 홈페이지에 기재되어 있으니 양해 부탁드립니다.
| 제품번호 | N0142 |
Purity/Analysis Method 
|
>95.0%(GC)(T) |
| M.F. / M.W. | C__6H__4ClNO__4S = 221.61 |
| 물리적 상태 (20 ℃) | Solid |
| 보관 조건
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 불활성 가스 하에서 보관 | Store under inert gas |
| 피해야 할 조건 | Moisture Sensitive |
| CAS RN | 1694-92-4 |
| Reaxys-RN | 521155 |
| PubChem Substance ID | 87573527 |
| SDBS | 4477 |
| MDL 번호 | MFCD00007430 |
규격표
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(GC) | min. 95.0 % |
| Purity(Argentometric Titration) | min. 95.0 % |
| Melting point | 64.0 to 70.0 °C |
물성치(참고치)
| mp | 64 °C |
| 용해성 (용해) | Toluene |
GHS
| 픽토그램 |
|
| 신호 워드 | Danger |
| 위험물 및 유해 등록 | H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| 주의 사항 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dusts or mists. P234 : Keep only in original container. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P390 : Absorb spillage to prevent material damage. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P406 : Store in corrosive resistant container with a resistant inner liner. P405 : Store locked up. |
법규 정보
운송 정보
| UN 번호 | UN3261 |
| 등급 | 8 |
| 포장 그룹 | II |
| HS 번호* | 2904.99-000 |
Application
TCI Practical Example: Nosylation of Amino Group Using o-Ns-Cl
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Used Chemicals
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Procedure
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To a solution of 4-methoxybenzylamine (1.00 g, 7.29 mmol) and triethylamine (1.11 mL, 8.02 mmol, 1.1 eq.) in dichloromethane (14.6 mL) was added o-Ns-Cl (1.70 g, 7.65 mmol, 1.05 eq.) at 0 °C and the mixture was stirred for 2 h at room temperature. The reaction mixture was quenched with 1 mol/L HCl aq. (14.6 mL) with cooling to 0 °C and the water layer was extracted with dichloromethane (4 x 10 mL). The combined organic layer was washed with brine, dried over sodium sulfate and filtered to give 1 as a pale yellow solid (2.32 g, 99% yield).
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Experimenter’s Comments
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The reaction mixture was monitored by TLC (ethyl acetate:hexane = 1:1, Rf = 0.6).
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Analytical Data
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Compound 1
1H NMR (270 MHz, DMSO-d6); δ 8.57 (t, J = 6.2 Hz, 1H), 7.75-7.92 (m, 4H), 7.15 (d, J = 8.8 Hz, 1H), 6.79 (d, J = 8.8 Hz, 1H), 4.08 (d, J = 6.2 Hz, 1H), 3.70 (s, 3H).
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Other Reference
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- PREPARATION OF SECONDARY AMINES FROM PRIMARY AMINES VIA 2-NITROBENZENESULFONAMIDES: N-(4-METHOXYBENZYL)-3-PHENYLPROPYLAMINE
Application
Ns-Protection of Primary Amino Groups
Typical Procedure:
To a 300 mL two-necked round-bottomed flask, 4-methoxybenzylamine (6.81 g, 49.6 mmol), 100 mL of dichloromethane and triethylamine (6.93 mL, 49.6 mmol) are added under nitrogen. The mixture is stirred and cooled with an ice bath while 2-nitrobenzenesulfonyl chloride (10.0 g, 45.1 mmol) is added over a period of 5 min. After 5 min, the ice bath is removed and the reaction mixture is stirred for 15 min at room temperature, and then quenched with 100 mL of 1 M-HCl. The aqueous layer is extracted with two 100 mL portions of dichloromethane, and the combined organic extracts are washed with 50 mL of brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 14.2 g of the crude product. Recrystallization from 500 mL of ethyl acetate/hexane (1:1) gives 13.00 g of N-(4-Methoxybenzyl)-2-nitrobenzenesulfonamide as white crystals (13.00 g, 90% yield).
To a 300 mL two-necked round-bottomed flask, 4-methoxybenzylamine (6.81 g, 49.6 mmol), 100 mL of dichloromethane and triethylamine (6.93 mL, 49.6 mmol) are added under nitrogen. The mixture is stirred and cooled with an ice bath while 2-nitrobenzenesulfonyl chloride (10.0 g, 45.1 mmol) is added over a period of 5 min. After 5 min, the ice bath is removed and the reaction mixture is stirred for 15 min at room temperature, and then quenched with 100 mL of 1 M-HCl. The aqueous layer is extracted with two 100 mL portions of dichloromethane, and the combined organic extracts are washed with 50 mL of brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 14.2 g of the crude product. Recrystallization from 500 mL of ethyl acetate/hexane (1:1) gives 13.00 g of N-(4-Methoxybenzyl)-2-nitrobenzenesulfonamide as white crystals (13.00 g, 90% yield).
References
PubMed Literature
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SDS
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