A Versatile and Safe Trifluoromethylthiolating Agent

N-Methyl-N-(trifluoromethylthio)aniline (1) is an electrophilic trifluoromethylthiolating agent and can be used for the reaction with various substances. For example, 1 smoothly reacts with Grignard reagents to afford the corresponding trifluoromethylthiolated products.¹⁾ In the reaction with terminal alkynes, the trifluoromethylthiolating reaction proceeds using catalytic amounts of base.²⁾ Furthermore, 1 can be applied to the trifluoromethylthiolation of indoles in the presence of a Brønsted or Lewis acid.^{3, 4)} 1 is a safe and liquid trifluoromethylthiolating agent that it is used for the synthesis of trifluoromethylthiolated compounds attracting attention in the pharmaceutical and agrochemical fields.