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CAS RN: 2140-61-6 | Product Number: M1931
5-Methylcytidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
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| Product Number | M1931 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__5N__3O__5 = 257.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 2140-61-6 |
| Reaxys Registry Number | 89657 |
| PubChem Substance ID | 87560073 |
| MDL Number | MFCD00006548 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +13.0 to +17.0 deg(C=2, H2O) |
Properties (reference)
| Melting Point | 211 °C(dec.) |
| Specific Rotation | 15° (C=2,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2940.00-000 |
Application
5-Methylcytidine: An Important Base-modified Ribonucleoside in Epigenetics
5-Methylcytidine (m5C) is a modified ribonucleoside that has long been known to be present in tRNA and rRNA.1) It is subject to oxidative processing in vivo to form 5-(hydroxymethyl)cytidine (hm5C) [H1863], which has roles in cell viability and development through these effects on RNA as follows; RNA structure and translation efficiency.2,3)
References
- 1) Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs
- 2) Formation and Abundance of 5-Hydroxymethylcytosine in RNA
- 3) Epitranscriptome sequencing technologies: decoding RNA modifications (a review)
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