Published TCIMAIL newest issue No.199
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 4097-22-7 | Product Number: D3065
2',3'-Dideoxyadenosine
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- ddA
- 9-(2,3-Dideoxy-β-D-ribofuranosyl)adenine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
€ 295,00
|
1 | 25 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | D3065 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3N__5O__2 = 235.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 4097-22-7 |
| Reaxys Registry Number | 619924 |
| PubChem Substance ID | 87559802 |
| SDBS (AIST Spectral DB) | 52173 |
| Merck Index (14) | 3101 |
| MDL Number | MFCD00010534 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| Specific rotation [a]20/D | -27.0 to -34.0 deg(C=1, H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C |
| Specific Rotation | -34° (C=1,H2O) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 223-853-2 |
| RTECS# | AU7358900 |
Transport Information:
| HS Number | 2934999090 |
Application
2',3'-Dideoxyadenosine (ddA): A Nucleoside Reverse Transcriptase Inhibitor
2',3'-Dideoxyadenosine (ddA) and didanosine (ddI) [D3066] are nucleoside reverse transcriptase inhibitors. ddA is a synthetic nucleoside analogue of the naturally occurring nucleoside 2’-deoxyadenosine in which the 3'-hydroxyl group is replaced by hydrogen. Intracellularly, ddA and ddI are converted by cellular enzymes to the active metabolite, ddA- 5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, 2’-deoxyadenosine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)
References
- Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides
- Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro
- Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.
- Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity
- Toxicity of Nucleoside Analogues Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase (a review)
PubMed Literature
Documents
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.