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Published TCIMAIL newest issue No.199
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CAS RN: 24356-66-9 | Product Number: V0098
Vidarabine Monohydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Ara-A Monohydrate
- Adenine 9-β-D-Arabinofuranoside Monohydrate
- 9-(β-D-Arabinofuranosyl)adenine Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€88.00
|
1 | 26 |
|
|
| 5G |
€286.00
|
1 | 15 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | V0098 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3N__5O__4·H__2O = 285.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 24356-66-9 |
| Related CAS RN
|
5536-17-4 |
| Reaxys Registry Number | 93029 |
| PubChem Substance ID | 87560128 |
| Merck Index (14) | 9976 |
| MDL Number | MFCD00065471 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -2.0 to -4.0 deg(C=1, DMF) |
| Drying loss | 5.0 to 7.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 253 °C |
| Specific Rotation | -3° (C=1,DMF) |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | AU6200000 |
Transport Information:
| HS Number | 2940000080 |
Application
Vidarabine: An Arabinosyladenine with Ant-Virus and Anti-Cancer Activities
Vidarabine (arabinosyladenine, ara-A) is a synthetic purine nucleoside, and was first synthesized by Lee et al. in 1960. Vidarabine was originally intended as an anti-cancer agent, while the anti-viral activity against herpesvirus and vaccinia virus was reported by Rudder et al in 1965. And also the activity against varicella-zoster virus was reported by Miller et al. in 1968. Vidarabine had a broad-spectrum activity against DNA viruses but little activity against RNA viruses. Vidarabine is converted to the active form vidarabine triphosphate (ara-ATP) which inhibits viral DNA polymerase activity in vitro and in vivo. (The product is for research purpose only.)
References
- Potential Anticancer Agents.1 Xl. Synthesis of the β-Anomer of 9-(D-Arabinofuranosyl)-Adenine
- Inhibitory effect of some nucleosides on the growth of various human viruses in tissue culture.
- Antiviral activity of 9-beta-D-arabinofuranosyladenine. I. Cell culture studies.
- Inhibition of Herpesvirus DNA Synthesis by 9-β-D-Arabinofuranosyladenine in Cellular and Cell-Free Systems
- The mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA)
- Vidarabine: a preliminary review of its pharmacological properties and therapeutic use
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