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Published TCIMAIL newest issue No.199
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CAS RN: 124832-27-5 | Product Number: V0111
Valacyclovir Hydrochloride
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Purity: >97.0%(HPLC)(N)
Synonyms:
- L-Valine 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-ylmethoxy)ethyl Ester Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€38.00
|
1 | 3 |
|
| 1G |
€234.00
|
1 | 19 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | V0111 |
Purity / Analysis Method 
|
>97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__3H__2__0N__6O__4·HCl = 360.80 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 124832-27-5 |
| Related CAS RN
|
124832-26-4&1218948-84-5 |
| Reaxys Registry Number | 14243859 |
| PubChem Substance ID | 125307930 |
| SDBS (AIST Spectral DB) | 52990 |
| Merck Index (14) | 9899 |
| MDL Number | MFCD01861507 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 %(calcd.on anh.substance) |
| Water | max. 6.0 % |
Properties (reference)
| Maximum Absorption Wavelength | 253 nm (H__2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
Valacyclovir Hydrochloride: A Prodrug of Antiviral Acyclovir
Valacyclovir hydrochloride is a prodrug of antiviral acyclovir [A1915] which is a nucleoside analog DNA polymerase inhibitor. It was developed to improve the pharmacokinetic characteristics of acyclovir. After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract by the intestinal peptide transporter (PEPT1) and converted to acyclovir and L-valine [V0014] by first-pass intestinal and/or hepatic metabolism. (The product is for research purpose only.)
References
- Amino acid ester prodrugs of acyclovir
- Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
- Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2
- Valacyclovir: a review of its antiviral activity, pharmacokinetic properties, and clinical efficacy (a review)
- Valaciclovir: A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in herpesvirus infections (a review)
- New drugs - reports of new drugs recently approved by the FDA. Valacyclovir (a review)
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