Maximum quantity allowed is 999
Please select the quantity
CAS RN: 2627-69-2 | Product Number: A2528
5-Aminoimidazole-4-carboxamide 1-β-D-Ribofuranoside
×
Purity: >98.0%(HPLC)
Synonyms:
- 5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide
- Acadesine
- AICAR
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
$96.00
|
≥40 | 0 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | A2528 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__4N__4O__5 = 258.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 2627-69-2 |
| Reaxys Registry Number | 38255 |
| PubChem Substance ID | 253659575 |
| Merck Index (14) | 16 |
| MDL Number | MFCD00869751 |
Specifications
| Appearance | White to Light yellow to Light red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -61.0 to -66.0 deg(C=1、H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 212 °C |
| Specific Rotation | -63° (C=1,H2O) |
| Maximum Absorption Wavelength | 265 nm (NaOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Autophagy research
References
- AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
- Inhibition of Hepatocytic Autophagy by Adenosine, Aminoimidazole-4-carboxamide Riboside, and N6-Mercaptopurine Riboside. EVIDENCE FOR INVOLVEMENT OF AMP-ACTIVATED PROTEIN KINASE
Application
Acadesine (AICAR): AMP-Activated Protein Kinase Activator
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (Acadesine or AICAR) has been extensively used in vitro and in vivo to activate AMP-activated protein kinase (AMPK). AMPK stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis. Therefore, acadesine may have applications in treating disorders such as type 2 diabetes and Alzheimer's disease. Recently, it has been shown that acadesine induces leukemia apoptosis. (The product is for research purpose only.)
References
- 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
- J. M. Corton, J. G. Gillespie, S. A. Hawley, D. G. Hardie, Eur. J. Biochem. 1995, 229, 558.
- AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
- G. F. Merrill, E. J. Kurth, D. G. Hardie, W. W. Winder, Am. J. Physiol. 1997, 273, E1107.
- Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
- T. Hayashi, M. F. Hirshman, E. J. Kurth, W. W. Winder, L. J. Goodyear, Diabetes 1998, 47, 1369.
- Knockout of the α2 but Not α1 5'-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside- but Not Contraction-induced Glucose Uptake in Skeletal Muscle
- 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase
- AMP-activated protein kinase and muscle glucose uptake (a review)
- AMP-activated protein kinase: a potential player in Alzheimer's disease (a review)
PubMed Literature
Documents
Product Documents (Note: Some products will not have analytical charts available.)
Enter TCI Product Number
Enter KISHIDA Product Number
4-5 alphanumeric characters before the hyphen
7 alphanumeric characters
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
• The requested SDS is not available.
Specifications
The requested specifications are not available.
Please Contact Us for more information.
The requested specifications are not available.
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us for more information.
• Please check that the lot number you have entered is correct. It is 7 alphanumeric characters. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
The requested analytical chart is not available. Sorry for the inconvenience.