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CAS RN: 58-08-2 | Product Number: C2042
Caffeine
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 1,3,7-Trimethylxanthine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25G |
$18.00
|
≥60 | ≥60 | It can be shipped in about 2 weeks after ordering | |
| 500G |
$63.00
|
2 | 35 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | C2042 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__0N__4O__2 = 194.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58-08-2 |
| Reaxys Registry Number | 17705 |
| PubChem Substance ID | 87558398 |
| Merck Index (14) | 1636 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in hot Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 238 °C |
| Solubility in water | Slightly soluble |
| Degree of solubility in water | 21.7 g/l |
| Solubility (soluble in) | Chloroform |
| Solubility (slightly sol. in) | Alcohol, Benzene, Acetone |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H332 : Harmful if inhaled. H360 : May damage fertility or the unborn child. H412 : Harmful to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P405 : Store locked up. |
Related Laws:
| RTECS# | EV6475000 |
Transport Information:
| UN Number | UN1544 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2939.30-000 |
Application
Efflux pump research
Caffeine is one of the methylxanthine compounds having activity as an efflux pump inhibitor in Staphylococcus aureus.1) Although having no antimicrobial effect itself, caffeine has been reported to show synergistic effects on antibiotics, carbenicillin (C2241), ceftizoxime (C2622), and gentamicin (G0383) in Pseudomonas aeruginosa and Staphylococcus aureus.2-4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) The inhibitory effect of fluphenazine decanoate and caffeine on Staphylococcus aureus efflux pumps
- 2) In vitro Evaluation of Methylxanthines and Some Antibiotics: Interaction against Staphylococcus aureus and Pseudomonas aeruginosa
- 3) Interaction of methylxanthines and gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa: Role of phosphodiesterase inhibition
- 4) Effects of Omeprazole and Caffeine Alone and in Combination with Gentamicin and Ciprofloxacin Against Antibiotic Resistant Staphylococcus Aureus and Escherichia Coli Strains
- 1) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use (a review)
- 2) Caffeine and adenosine (a review)
- 3) Regulation of the G2/M transition by p53 (a review)
- 4) The enigmatic effects of caffeine in cell cycle and cancer (a review)
Application
Caffeine: A Non-Selective Adenosine Receptor Antagonist, and an Inhibitor Cell Cycle of Progression
Caffeine is widely contained in foods and beverages and is the most widely consumed central-nervous-system stimulant.1) It has been known that adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Caffeine, a mimic of adenosine, has the opposite effect of adenosine, and causes most of its biological effects via antagonizing all types of adenosine receptors (ARs), such as A1, A2A, A3, and A2B.2) Besides, it has been reported that caffeine is capable of abrogating cell cycle checkpoints in several different mammalian cell types.3,4) Caffeine has been used to help delineate the role of p53 (cellular tumor antigen p53 gene) in the G2 arrest that occurs in response to DNA damage.3) (The product is for research purpose only.)
References
PubMed Literature
Documents
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