text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 3094-09-5 | Product Number: D3579

5'-Deoxy-5-fluorouridine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1-(5-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
  • 5'-dFUrd
  • Doxifluridine
Documents:
1G
$73.00
≥20  ≥20 
5G
$219.00
19   ≥20 

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number D3579
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__9H__1__1FN__2O__5 = 246.19  
Physical State (20 deg.C) Solid
CAS RN 3094-09-5
Reaxys Registry Number 890191
PubChem Substance ID 87559877
Merck Index (14) 3437
MDL Number

MFCD00866530

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 189.0 to 193.0 °C
Specific rotation [a]20/D +18.0 to +22.0 deg(C=1, H2O)
Properties (reference)
Melting Point 189 °C
Specific Rotation 20° (C=1,H2O)
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H373 : May cause damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P272 : Contaminated work clothing should not be allowed out of the workplace.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P280 : Wear protective gloves.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P314 : Get medical advice/ attention if you feel unwell.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
Related Laws:
RTECS# YU7526000
Transport Information:
Application
5'-Deoxy-5-Fluorouridine (Doxifluridine): A Prodrug of Active Antitumor 5-FU

5'-Deoxy-5-fluorouridine (doxifluridine) is a prodrug of active antitumor 5-FU [F0151] and an intermediary metabolite of capecitabine [C2878] and 5'-deoxy-5-fluorocytidine [D4342]. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine and doxifluridine, to form 5-FU. Capecitabine and its intermediary metabolites are not cytotoxic by themselves. The final step (doxifluridine to 5-FU) requires thymidine phosphorylase (dThdPase) that is significantly more active in tumor than normal tissue. This tumor-selective delivery of 5-FU ensured greater efficacy and a more favorable safety profile than with other fluoropyrimidines. (The product is for research purpose only.)

References


PubMed Literature


TCIMAIL
Documents
Safety Data Sheet (SDS) Search
Please select Language.

The requested SDS is not available.

• Please check that the Product Number you have entered is correct.

• If your information is correct and you are still not able to view the requested SDS,  please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number is entered
Other Documents