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CAS RN: 122111-03-9 | Product Number: G0367

Gemcitabine Hydrochloride


Purity: >98.0%(HPLC)(N)
Synonyms:
  • 2'-Deoxy-2',2'-difluorocytidine
  • dFdC
Documents:
100MG
$90.00
14   ≥20 
1G
$460.00
≥20  ≥20 

* Please contact our distributors or TCI to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.


Product Number G0367
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__9H__1__1F__2N__3O__4·HCl = 299.66  
Physical State (20 deg.C) Solid
CAS RN 122111-03-9
Related CAS RN 95058-81-4
Reaxys Registry Number 5386970
PubChem Substance ID 125307627
SDBS (AIST Spectral DB) 52896
Merck Index (14) 4386
MDL Number

MFCD01735988

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Specific rotation [a]20/D +46.0 to +49.0 deg(C=1, H2O)
Properties (reference)
Melting Point 292 °C
Specific Rotation 48° (C=1,H2O)
Maximum Absorption Wavelength 268(H2O) nm
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H361 : Suspected of damaging fertility or the unborn child.
H373 : May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P405 : Store locked up.
Related Laws: / Compliance with laws, Regulations
RTECS# HA3840000
Transport Information:
Application
Gemcitabine Hydrochloride: A Fluorinated Deoxycytidine Analog with Antitumor Activity

Gemcitabine [G0544] and its hydrochloride are fluorinated deoxycytidine analogs with antitumor activity against solid tumors. Once inside the cell, gemcitabine is rapidly phosphorylated by deoxycytidine kinase to form the active metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCDP inhibits ribonucleotide reductase, which is responsible for producing the deoxynucleotides required for DNA synthesis and repair. dFdCTP can be incorporated into DNA, leading to inhibition of DNA synthesis. On the other hand, a concomitant treatment with gemcitabine and cisplatin [D3371] is used for the treatment of several different types of cancer. Cisplatin acts by formation of platinum (Pt)-DNA adducts; gemcitabine acts by dFdCTP incorporation into DNA, subsequently leading to inhibition of exonuclease and DNA repair. (The product is for research purpose only.)

References


PubMed Literature


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