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CAS RN: 929895-45-4 | Product Number: P3182
Phen-DC3
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- Phen-DC3 Trifluoromethanesulfonate
- 3,3'-[(4a,6a-Dihydro-1,10-phenanthroline-2,9-dicarbonyl)bis(azanediyl)]bis(1-methylquinolin-1-ium) Trifluoromethanesulfonate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5MG |
$82.00
|
9 | ≥40 | It can be shipped in about 3-4 weeks after ordering | |
| 25MG |
$273.00
|
10 | 25 | It can be shipped in about 3-4 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | P3182 |
| Purity / Analysis Method | >95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__3__6H__2__6F__6N__6O__8S__2 = 848.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 929895-45-4 |
| Reaxys Registry Number | 11002833 |
| MDL Number | MFCD32067401 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.49-000 |
Application
Phen-DC3: A Guanine Quadruplex (G4) Specific Ligand
Guanine quadruplexes (G4s) are non-Watson-Crick four-stranded nucleic acid structures held together by noncanonical G-G base tetrads. Recent studies indicate their existence in vivo and their involvement in various biological processes.1) Phen-DC3 is a guanine quadruplex (G4) specific ligand that can inhibit helicases such as FANCJ that unwind G4 DNA. 2,3) FANCJ inhibitors have been used in cancer research because FANCJ mutations are associated with cancer. (The product is for research use only.)
References
- 1) G-quadruplex interacting small molecules and drugs: from bench toward bedside (a review)
- 2) Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA G-quadruplex DNA Structures That Threaten Genomic Stability
- 3) Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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