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CAS RN: 6398-98-7 | Product Number: A3133
Amodiaquine Dihydrochloride Dihydrate
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Dihydrochloride Dihydrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 5G |
$31.00
|
16 | 0 | Contact Us | |
| 25G |
$106.00
|
30 | 0 | Contact Us |
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| Product Number | A3133 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2ClN__3O·2HCl·2H__2O = 464.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6398-98-7 |
| Related CAS RN
|
86-42-0&69-44-3 |
| Reaxys Registry Number | 17163077 |
| PubChem Substance ID | 354335166 |
| Merck Index (14) | 572 |
| MDL Number | MFCD00078857 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Water | 7.0 to 9.0 % |
| NMR | confirm to structure |
Properties (reference)
| Maximum Absorption Wavelength | 342 nm (MeOH) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Alcohol |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.49-000 |
Application
Amodiaquine Dihydrochloride: A 4-Aminoquinoline Antimalarial Agent
Amodiaquine dihydrochloride is a synthetic 4-aminoquinoline antimalarial agent. Amodiaquine is mainly metabolized hepatically towards its major active metabolite N-desethylamodiaquine, by the cytochrome P450 2C8 (CYP2C8). The mechanism of action of amodiaquine against plasmodium is not yet completely understood, but the most plausible explanation is that the active metabolite penetrate the infected red blood cells and prevent the parasite from polymerizing heme into a malarial metabolite called hemozoin, leading to parasite death. Recently, the antimalarial combination of amodiaquine plus artesunate [A2191] has been extensively studied and good efficacy and tolerability has been reported. (The product is for research purpose only.)
References
- Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate (a review)
- CYP2C8 and antimalaria drug efficacy (a review)
- Artemisinin-based combination treatment of falciparum malaria
- Amodiaquine hydrochloride (a review on the synthesis, properties, analysis and pharmacology)
- High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples
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