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CAS RN: 12650-69-0 | Product Number: M2955
Mupirocin
×
Purity: >98.0%(T)
Synonyms:
Product Documents:
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| Product Number | M2955 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__6H__4__4O__9 = 500.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 12650-69-0 |
| Reaxys Registry Number | 4726470 |
| PubChem Substance ID | 354334600 |
| Merck Index (14) | 6302 |
| MDL Number | MFCD01711620 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 92.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -18.0 to -21.0 deg(C=1,MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 78 °C |
| Specific Rotation | -19° (C=1,MeOH) |
| Maximum Absorption Wavelength | 222 nm (EtOH) |
GHS
Related Laws:
| RTECS# | RA6907000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
RNA合成酵素を阻害する抗生物質，ムピロシン
Mupirocin is a polyketide antibiotic produced by fermentation using the organism Pseudomonas fluorescens. Mupirocin is fungicidally active against a wide range of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Mupirocin is also active against certain Gram-negative bacteria. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to its mode of action, mupirocin does not demonstrate cross resistance with other classes of antibiotic agents. The calcium salt of mupirocin is used as an ointment to control the carriage of MRSA on skin and in nasal passages as well as for various skin infections. Recently, mupirocin resistance in Staphylococcus aureus is increasingly being reported in many parts of the world. (The product is for research purpose only.)
References
- Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Echerichia coli by pseudomonic acid
- Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use
- Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use (a review)
- Insights into editing from an Ile-tRNA synthetase structure with tRNAIle and mupirocin
- Mupirocin resistance (a review)
- Resistance to and synthesis of the antibiotic mupirocin (a review)
- Development and validation of RP-HPLC method for simultaneous estimation of prednicarbate, mupirocin and ketoconazole in topical dosage forms
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