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CAS RN: 61379-65-5 | Product Number: R0198
Rifapentine
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Purity: >98.0%(HPLC)
Synonyms:
- 3-[[(4-Cyclopentyl-1-piperazinyl)imino]methyl]rifamycin
- Cyclopentylrifampicin
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$172.00
|
8 | 18 | Contact Us | |
| 500MG |
$603.00
|
12 | 3 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | R0198 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__7H__6__4N__4O__1__2 = 877.05 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 61379-65-5 |
| Reaxys Registry Number | 1071099 |
| PubChem Substance ID | 468592781 |
| Merck Index (14) | 8219 |
| MDL Number | MFCD00866806 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 174 °C |
| Maximum Absorption Wavelength | 475 nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | JQ0902000 |
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Rifapentine: A Long Lasting Rifamycin against Tuberculosis
Rifapentine, a cyclopentyl-substituted rifamycin is an anti-mycobacterial agent. Rifapentine is a long lasting rifamycin whose serum half-life is five times that of rifampicin [R0079]. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis but does not affect mammalian cells at concentrations that are active against these bacteria. In clinical, the combination therapy using rifapentine and isoniazid [I0138] is also used for the treatment of latent tuberculosis infection. (The product is for research purpose only.)
References
- Bactericidal activity in vitro of various rifamycins against Mycobacterium avium and Mycobacterium tuberculosis
- Rifapentine (a review)
- The near future: improving the activity of rifamycins and pyrazinamide (a review)
- Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS
- Validation of a simple HPLC-UV method for rifampicin determination in plasma: Application to the study of rifampicin arteriovenous concentration gradient.
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