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Published TCIMAIL newest issue No.201
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CAS RN: 136470-78-5 | Product Number: A2694
Abacavir
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€78.00
|
2 | 25 |
|
|
| 5G |
€273.00
|
3 | 15 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | A2694 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__8N__6O = 286.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 136470-78-5 |
| Reaxys Registry Number | 7493116 |
| PubChem Substance ID | 253661597 |
| Merck Index (14) | 1 |
| MDL Number | MFCD00903850 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -53.0 to -57.0 deg(C=0.15, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 161 °C(dec.) |
| Specific Rotation | -54° (C=0.15,MeOH) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P261 : Avoid breathing dust. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
Related Laws:
| RTECS# | GY5979200 |
Transport Information:
| HS Number | 2933599590 |
Application
Abacavir: A Nucleoside Analog Reverse Transcriptase Inhibitor (RTI)
Abacavir is a nucleoside analog reverse transcriptase inhibitor (RTI) that inhibits HIV-1 in vitro with a potency similar to that of zidovudine [A2052]. Resistance to abacavir develops relatively slowly. Cross-resistance between abacavir and other RTIs, namely didanosine [D3066], zalcitabine [D3581] or lamivudine [L0217], but not zidovudine or stavudine [D3580], has been reported in vitro. HLA-B*5701 genetic screening have been reported to prevent drug hypersensitivity reactions caused by abacavir.
References
- Abacavir (a review)
- The antiviral activity, mechanism of action, clinical significance and resistance of abacavir in the treatment of pediatric AIDS (a review)
- HLA-B*5701 screening prior to abacavir prescription: Clinical and laboratory aspects (a review)
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV (a review)
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