2,4-Dibromo-6-[(E)-[[(1R,2R)-2-(isoindolin-2-yl)-1,2-diphenylethyl]imino]methyl]phenol

Experimental procedure: N-Ts alkenamide (0.1 mmol) and D5160-CuOAc complex (7.0 mg, 0.01 mmol) are dissolved in dichloromethane (1 mL) and toluene (3 mL). The mixture is stirred at room temperature for 10 min, and at -78 °C for 30 min. Then, NIS (24.6 mg, 0.11 mmol) and I₂ (5.1 mg, 0.02 mmol) are added to the reaction mixture. After being stirred for 16-18 h, the reaction mixture is quenched with saturated Na₂SO₃ aq. and then the products are extracted with dichloromethane in 3 times. The collected organic layer is dried over Na₂SO₄. After removal of the solvent under reduced pressure, the residue is purified by silica-gel column chromatography (hexane:ethyl acetate = 3:1) to afford the iodocyclization product.