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CAS RN: 129453-61-8 | Product Number: F1144
Fulvestrant
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Purity: >98.0%(HPLC)
Synonyms:
- (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol
- ICI 182780
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
€81.00
|
1 | 10 |
|
|
| 100MG |
€241.00
|
1 | 28 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | F1144 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__3__2H__4__7F__5O__3S = 606.78 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 129453-61-8 |
| Reaxys Registry Number | 7734375 |
| PubChem Substance ID | 468591825 |
| MDL Number | MFCD00903953 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]25 | +108 to +115 deg(365nm, C=2, methanol) |
Properties (reference)
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.00001 g/l 25 °C |
| Solubility (soluble in) | Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P273 : Avoid release to the environment. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | KG7623000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2937290000 |
Application
Fulvestrant: An Estrogen Receptors Antagonist with a Unique Structure and Mode of Action
Many breast cancers have estrogen receptors (ERs) and the growth of these tumors can be stimulated by estrogen. ER antagonists bind to ER and downregulate the ER protein in breast cancer cells. Fulvestrant (ICI 182,780) is an ER antagonist with a unique structure and mode of action. It not only binds competitively to the ER with high affinity, but also acts as a degradation inducer of ER with its long alkyl side chain. Therefore, fulvestrant has been reported to help circumvent resistance to “pure” ER antagonists, such as tamoxifen citrate [T2510]. For your reference, [D5471] is a key synthetic intermediate of fulvestrant. (The product is for research purpose only.)
References
- A Potent Specific Pure Antiestrogen with Clinical Potential
- Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens
- Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action (a review)
- Fulvestrant: a review of its use in the management of hormone receptor-positive metastatic breast cancer in postmenopausal women
- Pharmacokinetic profile of intramuscular fulvestrant in advanced breast cancer
- Determination of Fulvestrant in Rat Plasma by LC-MS-MS: Application to a Pharmacokinetic Study
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